Zain Khalpey, MD, PhD, FACS, FETCS, MRCS (Eng)

Dr. Zain Khalpey is an internationally recognized cardiothoracic surgeon, innovator, and Origin Partner whose work bridges advanced heart failure, artificial intelligence, and mechanical circulatory support. He serves as the Medical Director for the Total Artificial Heart, Mechanical Circulatory Support, and Extracorporeal Life Support (ECMO) program, and leads the Network Director for Artificial Intelligence.

Dr. Khalpey completed his medical training at Guy’s, King’s & St. Thomas’ Hospital, London School of Medicine, followed by residency and fellowship at Brigham & Women’s Hospital, Harvard Medical School. He went on to complete a super-fellowship in mechanical circulatory support at Columbia University’s New York Presbyterian Hospital. His PhD in Cardiothoracic Surgery, Bioenergetics, and Cardiac Transplantation was conducted through Imperial College London, with research performed across the University of Gdansk in Poland, Mayo Clinic in Minnesota, and Harvard University.

In 2016, Dr. Khalpey was appointed Distinguished Fulbright Chair in Medical Sciences—one of the most prestigious honors in the Fulbright Scholar Program. In 2020, he received the Robert Wood Johnson Foundation grant for his pioneering use of artificial intelligence to predict silent hypoxia in COVID-19 patients.

Dr. Khalpey leads Origin’s Artificial Intelligence Lab focused on predictive analytics in cardiovascular, oncology and neuroscience medicine.